“GMA” Exclusive interview focuses on Venus William’s diagnosis of the rare disease that affects 1.3 million people. For more information, click here: http://abcnews.go.com/Health/w_MindBodyNews/venus-williams-sjogrens-syndrome/story?id=14426884

UPDATE:
My Functional Dr cured me of all my autoimmunes:
Dr Anderson drhoustonanderson.com He just came out with the online courses!!!! https://drhouston.podia.com/the-sjogren-s-solution/9pq33

https://drhouston.podia.com/dr-houston-anderson-pllc-community/9pq33 https://drhouston.podia.com/a/9pq33

Going vegan DID cause my autoimmunes. I am so grateful to say I am 100% healthy. Do NOT give up! I hope that this helps you. http://elleisforliving.blogspot.com/2019/04/curing-sjogrens-autoimmune-and.html
Curing Auto Immune: https://www.youtube.com/watch?v=Mcf7P7vfHv8

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A whiteboard animation describing the Huntington’s Disease. Brought to you by the HOPES team at Stanford.
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Injury meaning in Hindi | Injury ka kya matlab hota hai | daily use English words

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इस वीडियो में आप Injury का हिंदी में मतलब समझेंगे और साथ में Injury का pronunciation भी सीखेंगें यानि की आप Injury के अर्थ के साथ साथ ये भी सीखेंगें की Injury को कैसे बोले या Injury को बोलने का सही तरीका क्या है |

On this channel, we provide online English speaking classes and spoken English course online which can improve your English with our English language course online. We are providing English speaking course online so that you can improve your English at your home and without paying any money for this. In this video, you will learn daily use English words which will improve to learn English vocabulary in a simple way. This video will help you to learn English through Hindi thus you can increase English vocabulary on a daily basis.

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तो बस एक मिनट में सीखिए Injury को|
Let’s learn Hindi Meaning of Injury in detail.

Injury का हिंदी में अर्थ होता है
चोट, घाव, ज़ख्म, क्षति, आघात

Injury को इन उदाहरणों से और अच्छे से समझ सकते हैं
He is recovering from a knee injury.

वह घुटने की चोट से उबर रहा है।

She’s unable to play because of injury.

वह चोट के कारण खेलने में असमर्थ है।

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#LearnEnglishThroughHindi #InjurymeaninginHindi #Injurymeaning #dailyuseenglishwords #englishvocabularyforbeginners
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injury meaning in hindi
injury ka matlab kya hota hai
english to hindi
word meaning
what injury
injury का हिंदी अर्थ

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Huntington’s disease (HD), also known as Huntington’s chorea, is a neurodegenerative disease that is mostly inherited.[7] The earliest symptoms are often subtle problems with mood or mental abilities.[1] A general lack of coordination and an unsteady gait often follow.[2] It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea.[8][9] As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent.[1] Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk.[1][2] Mental abilities generally decline into dementia.[3] The specific symptoms vary somewhat between people.[1] Symptoms usually begin between 30 and 50 years of age but can start at any age.[3][4] The disease may develop earlier in each successive generation.[1] About eight percent of cases start before the age of 20 years, and are known as juvenile HD, which typically present with the slow movement symptoms of Parkinson’s disease rather than those of chorea.[3]

HD is typically inherited from an affected parent, who carries a mutation in the huntingtin gene (HTT).[4] However, up to 10% of cases are due to a new mutation.[1] The huntingtin gene provides the genetic information for huntingtin protein (Htt).[1] Expansion of CAG repeats of cytosine-adenine-guanine (known as a trinucleotide repeat expansion) in the gene coding for the huntingtin protein results in an abnormal mutant protein (mHtt), which gradually damages brain cells through a number of possible mechanisms.[7][10] Diagnosis is by genetic testing, which can be carried out at any time, regardless of whether or not symptoms are present.[5] This fact raises several ethical debates: the age at which an individual is considered mature enough to choose testing; whether parents have the right to have their children tested; and managing confidentiality and disclosure of test results.[2]

No cure for HD is known, and full-time care is required in the later stages.[2] Treatments can relieve some symptoms, and in some, improve quality of life.[3] The best evidence for treatment of the movement problems is with tetrabenazine.[3] HD affects about 4 to 15 in 100,000 people of European descent.[1][3] It is rare among Japanese, while the occurrence rate in Africa is unknown.[3] The disease affects men and women equally.[3] Complications such as pneumonia, heart disease, and physical injury from falls reduce life expectancy.[3] Suicide is the cause of death in about 9% of cases.[3] Death typically occurs 15–20 years from when the disease was first detected.[4]

The earliest known description of the disease was in 1841 by American physician Charles Oscar Waters.[11] The condition was described in further detail in 1872 by American physician George Huntington.[11] The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation.[12][13] Research and support organizations began forming in the late 1960s to increase public awareness, provide support for individuals and their families and promote research.[13][14] Research directions include determining the exact mechanism of the disease, improving animal models to aid with research, testing of medications and their delivery to treat symptoms or slow the progression of the disease, and studying procedures such as stem-cell therapy with the goal of replacing damaged or lost neurons.[12]

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Neurology – Topic 17 Huntingtons disease – patient
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Huntington’s disease: Genetics, Neurology & Clinical Aspects, Diagnosis and Treatments
Huntington disease is a rare genetic disease that can give rise to involuntary movements like Huntington chorea.
**UPDATE: How Close are We to Curing Huntington Disease? Read my article on our Blog here: https://tinymedicine.org/?p=56

Today, we’ll explore the genetic basis of Huntington disease and the Neurological basis of chorea.
• This is the short arm of chromosome 4. It is the home of the Huntington gene which codes for the Huntington protein. All humans have two copies of this gene. It has a section called trinucleotide repeat, which is a sequence of three DNA bases, Cytosine, Adenine, and Guanine, repeated multiple times.
• A mutation in this gene can further increase the repeat count. If the repeat count is over 40, this will result in a very long Huntington protein called mutant Huntington protein. It can increase the decay of certain neurons in the brain.
• This gene is inherited as autosomal dominant. You get two copies of the gene from each parent. But since it’s dominant, one mutant copy is enough to give you the disease.
• The other important feature is its penetrance close to one hundred percent.
o It means that almost all the people with the mutant gene will develop the disease.
Symptoms typically arise after the age of 35-44. The age of onset depends on the number of the repeat count of the mutation. Symptoms may arise in the childhood itself if the repeat count is very high.
At first, they develop cognitive changes and mood changes like depression.
Later, the patients will develop speech and swallowing difficulty.
Finally, they will develop jerky, uncontrollable dancing like movements called chorea.
The brain learns and stores different motor patterns in the cerebral cortex. A structure called basal ganglia keeps these motor patterns switched off via a pathway called the indirect pathway. When you want to initiate a certain movement, the motor cortex signals the basal ganglia to activate the specific motor patterns. Activation occurs via a pathway called the direct pathway. In Huntington’s disease, neurons in the indirect pathway are decayed. Therefore the brain loses the ability to switch off the motor patterns. This results in uncontrollable movement such as chorea.
The presence of symptoms and positive family history is used to come to a clinical diagnosis. Genetic testing can confirm if an adult or an embryo carries the mutant Huntington Gene.
At the moment, there’s no cure for Huntington disease Drugs such as antipsychotics are given to control the movement. Supportive care includes occupational therapy, nutritional support and speech and language therapy. A new clinical trial tests a gene silencing drug to slow down the disease progression. But the hope for a complete cure is gene editing. Let’s hope the mankind will reach there soon.

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