Forbidden Fitness Secrets Of A Modern Day Ninja Warrior
Forbidden Fitness Secrets is used by legendary Japanese Shadow Warriors to reinforce Joints, Ligaments And Tendons to an almost Supernatural Breaking Point.
Now, even someone who is super-stiff, immobile, and out of shape can, in just a few short hours, know more about becoming near-invincible in the gym than most athletes, weightlifters and strength coaches do and do it in the fastest way possible!
UVA Neurologist Madaline Harrison, MD explains the signs of Huntington’s Disease.
Huntington’s disease is a rare genetic disorder that causes programmed degeneration of brain cells, called neurons, in certain areas of the brain. This talk explores the diagnosis, stages of the disease, and its treatment. The Stanford Huntington’s Disease and Ataxia Clinic has been named a Center of Excellence by the Huntington’s Disease Society of America. This talk reflects the treatment standards offered at Stanford.
Speaker: Veronica Santini, MD Clinical Instructor, Neurology and Neurological Sciences, Stanford University Medical Center
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This girl has six fingers on her left hand. She has a condition called polydactyly, which causes extra fingers or toes. Her father and grandmother as well as some of her cousins also have the condition. This should give you a clue about how she came to have it… any ideas? Well, polydactyly is an example of a genetic disorder – it is inherited. You inherit genes from your parents, and you have two copies of each gene – one from your mother and one from your father. Genes come in different forms, called alleles. Alleles may be recessive or dominant.
So going back to Polydactyly… Polydactyly is caused by a dominant allele, shown as a capital P. You only have to have one copy of this allele to have the condition. So in an example the father has a copy of this allele, but the mother does not… Offspring with one dominant allele big P, and one recessive allele little p will also have the condition. Whereas these offspring won’t have the condition. Can you see what their genotype must be…? Little p, little p – so two copies of the recessive allele.
Another example of an inherited disorder is cystic fibrosis. If you want to discover more about cystic fibrosis, and how it affects the body then watch this video [insert link to ‘cystic fibrosis’ video].
Cystic fibrosis is inherited in a different way to polydactyly. Take a look at this genetic diagram and see if you can figure out how it is different.
To have cystic fibrosis, you have to inherit two recessive alleles. The parents in the diagram are both carriers of the recessive allele, little f. They do not have the disorder themselves but they could both pass the recessive allele to their children.
Quite often, people do not know they are carriers of cystic fibrosis until they have a child with the disorder. This can be very upsetting, as it is a serious condition.
Parents are able to make sure they do not have another child with the disorder using embryo screening.
Let’s finish off with a little discussion about what embryo screening is.
Embryo screening can be used to ensure embryo’s do not suffer from inherited genetic disorders.
To do this, the parents would use in-vitro fertilisation, which is also known as IVF.
IVF is where eggs and sperm are mixed in a dish in a lab outside of the body. Each fertilised egg would be left to grow until it reached a few cells big, and then one cell from each embryo is removed and its genes tested to see if it has the genetic disorder. Only unaffected embryos – a maximum of two – would be placed back into the mother’s uterus to grow and hopefully develop into a healthy baby.
There are many issues surrounding embryo screening. One ethical issue is that the unused embryos, potential lives, are destroyed. Also, there are social concerns – IVF is not always successful and this can be upsetting for the parents and their family. Finally there are also economic issues because IVF is an expensive process.
So there we have a few examples of inherited genetic disorders. These are inherited from your parents, resulting from certain alleles your parents have been carriers of.
Sometimes genetic disorders are caused by dominant alleles – like polydactyly so it can be inherited from one parent – and others are caused by recessive alleles – like cystic fibrosis – so both parents need to carry the allele.
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This video “Causes of Heart Failure” is part of the Lecturio course “Cardiology” ► WATCH the complete course on http://lectur.io/causesofheartfailure
► LEARN ABOUT:
– Population attributable risk factors
– Ischemic heart disease
– Rarer causes of heart failure
– Abuse of drugs such as alcohol and cocaine and their effect on the heart
► THE PROF:
Your lecturer is Joseph Alpert M.D. He is Professor of Medicine at the Sarver Heart Center as well as Director of Coronary Care and Medical Director of Cardiac Rehabilitation at the University of Arizona. Additionally, he is a member of the most important cardiologic institutions such as the American Heart Association and the European Society of Cardiology. Because of his outstanding teaching proficiency he is board certified in internal medicine and cardiovascular disease and has won many teaching awards such as the George W. Thorn Award for Excellence in Teaching, the William Osler Master Teacher Award, and the Edward Rhodes Stitt Award for Outstanding Teaching. Furthermore, he received the Distinguished Achievement Award from the Clinical Cardiology Council of the American Heart Association and was selected “Gifted Teacher of the Year” in 2004 by the American College of Cardiology.
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What is Coronary Heart Disease? Coronary heart disease or CHD refers to a narrowing of the coronary arteries, the blood vessels that supply oxygen and blood to the heart.
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It is also known as coronary artery disease and it is the
leading cause of death worldwide. It is a major cause of illness and death. Coronary heart disease
normally happens when fatty deposits called cholesterol accumulates on the artery walls,
creating plaques. The arteries narrow, reducing blood flow to the heart. Sometimes, a clot can
obstruct the flow of blood to the heart muscle. CHD commonly causes angina pectoris (chest
pain), shortness of breath, myocardial infarction, or heart attack. A heart attack is the sudden
slowing or stopping of contractions of the heart muscles. This could be due to malfunction of the
cardiac muscles. Part of the heart muscle dies due to lack of oxygen. Heart attacks can also lead
to death.
CHD can also be caused by hypertension, coronary thrombosis, arteriosclerosis and
atherosclerosis. Hypertension is also known as high blood pressure, it is when our blood
pressure, the force of blood flowing through your blood vessels, is consistently too high.
Coronary thrombosis is forming of blood clot or thrombus in the artery. It is most likely to occur
in narrow arteries. Arteriosclerosis and atherosclerosis is the narrowing and hardening of arteries.
This happens due to cholesterol deposition on them. Most of the blocks in the artery are caused
by a combination of atheroma and thrombus. When this bloackage occurs it is called coronary
occlusion.
Causes of Coronary Heart Disease
CHD can be caused due to unhealthy lifestyle habits and even genetics. Certain mutations in the
genes are linked to this disease. A study published in PLOS in 2017, even linked CHD to food
preparation on high heat. Unhealthy diet rich in cholesterol and saturated fats, leads to high
blood cholesterol level. Smoking increases heart rate and blood pressure, this causes blood to
clot more easily. Carbon monoxide in cigarette smoke replaces some of the oxygen in our blood.
This increases our blood pressure and heart rate by forcing our heart to work harder to supply
enough oxygen.
Women who smoke and take birth control pills are at greater risk of having a heart attack or
stroke than are those who do not smoke or take birth control pills, because both can increase the
risk of blood clots. Tobacco has toxins, which reduces the blood’s ability to carry oxygen. Stress
releases adrenaline, which increases heart rate and blood pressure.
Prevention
A diet rich in fruits, vegetables and whole grains can help protect your heart. Aim to eat beans,
low-fat or fat-free dairy products, lean meats, and fish as part of a healthy diet. Avoid too much
salt and sugars in your diet. Limiting certain fats you eat also is important. Exercise regularly and
maintain weight. Stop or do not start smoking. Avoid all forms of tobacco use, as all are equally
harmful. Reduce stress in your life.
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